Dual Core: A Mechanical, Biological, and Metabolic Model for Physiological Bio-regeneration with PEG-Crosslinked Hyaluronic Acid Fillers

Abstract

  This proof-of-concept article introduces the “Dual Core Concept”, a novel facial rejuvenation model integrating complementary mechanical, biological, and metabolic processes within a single synergistic framework. The concept focuses on Neauvia Stimulate, a PEG-crosslinked hyaluronic acid (PEG-HA) filler enriched with calcium hydroxyapatite (CaHA), which intrinsically embodies two “cores”: the mechanical core providing immediate structural lift and the biological core inducing progressive dermal regeneration. To reinforce deep anatomical support, Neauvia Intense may be used concomitantly as a structural scaffold, optimizing the environment for superficial and mid-fat layer regeneration. Drawing on histological, clinical, and biochemical evidence, this model illustrates the evolution of aesthetic medicine from volumetric correction toward physiological bio-regeneration, emphasizing precise anatomical targeting and the “less-is-more” principle of natural tissue restoration. This integrative approach represents a paradigm shift from static correction to functional, multi-layered rejuvenation aligned with the physiology of facial tissues.