Journal of Applied Cosmetology

Biological basis of the aesthetic and rejuvenating effects in the skin after the application of the compressive microvibration Endospheres.

Mon, 24 Jun 2024 00:00:00 +0000

Compressive microvibration is a type of stimulation patented as Endospheres therapy. The stimulation, through Endospheres, applied externally to the skin surface, causes changes in the physiological and functional structure of tissues underneath the epidermis, including adipose tissue. Cyclic mechanical stress, induced by this therapy with its particular compressive microvibration, modifies the normal cell cycle of adipose tissue and promotes tissue remodelling due to the activation of the abundantly present mesenchymal-derived stem cells. In this study, a literature revision was performed to elucidate the mechanisms through which the repetitive, cyclic or modulated/ordered mechanical input of Endospheres, which results in harmonic compressive microvibrations, can have beneficial effects on the skin and all subcutaneous tissues up to the muscles, improving rejuvenation, tissue repair, vascularization and macro-organization. It was possible to formulate the hypothesis that the ordered frequency and oscillatory dynamics can completely change the chaotic and oscillatory patterns of mitochondria alongside the endoplasmic reticulum membrane in a recently discovered complex known as mitochondria-associated endoplasmatic reticulum membrane complex or mitochondria-associated endoplasmatic reticulum membrane. Analyzing the biochemical and physical characteristics of these structures, it was assessed that the nature of the benefits of the Endospheres stimulation of tissues could include three different origins: mechanical, linked to the transfer of mechanical inputs; biophysical, related to the chaotic biology of mitochondria, the generation of sinusoidal waves and the generation of piezoelectric forces; and biochemical, linked to the sensory function of adipose tissue. All these forces are discussed in detail.

Generative medicine - towards a systematization of mechanical compressive microvibration treatments in aesthetic, regenerative, and anti-aging medicine: theoretical bases, tissue targets, and classification

Thu, 05 Sep 2024 00:00:00 +0000

Regenerative medicine is the new frontier of medicine, with a high degree of translationality, which involves different medical specializations, engineering, and information technology. It has as a target the human tissues. Lesions not yet irreversible become treatable. Aging can be re-discussed. In fact, preventive treatments arise; among these, the minimally invasive are particularly interesting. Mechanical treatments are included in the latter. A precise new classification of mechanical treatments was performed in this study. In particular, a detailed analysis was performed relating to mechanical compressive microvibration therapy. Both the tissue target and the bio-physical effects of this treatment were evaluated. All the aspects were analyzed to correlate theoretical expectations with the preliminary results of a research project. The regenerative effects appeared clear, and the absence of tissue damage was remarkable. For these reasons, mechanical compressive microvibration therapy can be included in the typology of mechanical regenerative therapies.

Immune system triggers as a factor for the formation of foreign body granuloma after hyaluronic acid fillers treatment.

R. Denkova, I. Georgieva, V. Kantardjiev — Fri, 07 Jun 2024 00:00:00 +0000

Injections of hyaluronic acid dermal fillers are minimally invasive cosmetic procedures that in general are considered safe. However, a lot of complications have been reported for the last couple of years. The formation of foreign body granuloma is a rare side effect which usually happens weeks to months after the injection of soft tissue fillers and is one of the most challenging when it comes to management. This study aims to report a case of foreign body granuloma formation after full face treatment with 12 ml of hyaluronic dermal fillers. A short overview of the main factors influencing granuloma formation and a treatment protocol are also presented.

Redox homeostasis and pH monitoring: a step forward to personalized medicine and dermatology

T. Lotti, H. Kocic, K. M. Lomonosov — Mon, 26 Aug 2024 00:00:00 +0000

Skin is continually subjected to various environmental stressors, such as pollution, UV rays, and other oxidative damage factors. It is obligatory to ascertain the exact importance of redox status and ROS indicators, which may be assessed in diverse physiological fluids and tissues. Reactive oxygen species (ROS) can cause lipid peroxidation, which can compromise the integrity and functionality of skin cells by degrading membrane lipids. This may compromise the skin barrier, making the skin more prone to infections and environmental irritants, increasing water loss and dryness. Collagen in the dermis can covalently link to malondialdehyde (MDA), a byproduct of lipid peroxidation generated by oxidatively damaged skin lipids, to form MDA-collagen adducts. Several types of skin cancer are associated with a heightened vulnerability of DNA purine and pyrimidine bases to oxidative damage and altered DNA repair capacity (DRC). Damage from ROS may cause hyaluronate to become less viscous, which increases its susceptibility to degradation. Elastin hydrodynamic radius decreased the rate of self-assembly in response to ROS. Alterations in redox homeostasis can lead to various diseases and conditions, including vitiligo, actinic keratosis, psoriasis, contact dermatitis, systemic sclerosis, the onset of wrinkles, and skin aging. The most recent formulations' capacity to improve pH and Redox simultaneously can be attained by carefully selecting proposed antioxidant formulations. The combination of modern preparations is currently available and should be used in accordance with the suggested guidelines.

Bipolar Radiofrequency Combined with Non-Crosslinked Hyaluronic Acid Mesotherapy: A Protocol for Skin Enhancement

D. Pereira Forjaz, M. Vassalo Forjaz — Mon, 14 Oct 2024 00:00:00 +0000

Changes associated with aging, such as alterations in epidermal hydration, pigmentation, thickness, and cell renewal, impact skin appearance and may result in laxity, dryness, and uneven skin tone. This case series aimed to evaluate the combined effects of bipolar radiofrequency and non-crosslinked hyaluronic acid mesotherapy on skin appearance, with the goal of achieving synergistic benefits. This retrospective data analysis included subjects aged 33-67 years with facial skin dryness and laxity. Subjects received treatment with a bipolar radiofrequency device on the face, followed immediately by mesotherapy with 2.5 ml of non-crosslinked hyaluronic acid. Photographic documentation and skin analysis were conducted before treatment and 30 days post-treatment. Fourteen subjects with a mean age of 45 years (range 33-67) and presenting with dry, lax facial skin were included. All measured indicators showed significant improvement following the combined radiofrequency and mesotherapy protocol. The combined protocol also correlated with greater improvement in both patient and physician satisfaction, observed immediately after the procedure and at 30 days post-procedure. The treatment was well tolerated, and no adverse events were reported. The combination of bipolar radiofrequency and non-crosslinked hyaluronic acid mesotherapy resulted in significant improvements in skin appearance, firmness, tone, and overall subject satisfaction compared to the baseline condition. The treatments were well received, leading to noticeable enhancements in facial aesthetics. No adverse events were reported, confirming the safety of the protocol.

Non-crosslinked hyaluronic acid mesotherapy and hydro-exfoliation plus infrared technology: a combination protocol to improve skin quality

R. F. de Castro Isalguez, E. M. Fernández — Fri, 22 Nov 2024 00:00:00 +0000

Smooth, healthy-looking skin is a desired aesthetic goal for all age groups. This study evaluated a new protocol combining non-crosslinked hyaluronic acid (HA) with hydro-exfoliation and infrared technology for improving skin quality parameters. This retrospective, single-center medical data analysis included subjects aged 18 to 65 in good general health, with signs of skin atrophy or aging in the face or neck area. On Day 0, subjects underwent mesotherapy with injections of non-crosslinked HA (18 mg/mL) with 0.01% calcium hydroxyapatite, glycine, and l-proline to a depth of 0.5 to 4 mm. On Day 7, this was followed by treatment with a combined hydro-exfoliation and infrared device. Visual improvements in skin quality parameters (wrinkles, pores, brown spots, texture, and oiliness) were assessed by a blinded evaluator using photographs taken prior to treatment and 2 weeks after the final treatment with a facial analysis imaging system. The medical data analysis included 22 subjects with a mean age of 45 years (range 28 to 65 years). Comparison of post-treatment with baseline images showed improvements in wrinkles of 13%-23%, pores of 16%-30%, skin texture of 15%-28%, and oiliness of 10%-33%; brown spots improved by 0.1%-0.7%. All treatments were well tolerated. In conclusion, the combination of non-crosslinked HA mesotherapy, hydro-exfoliation, and infrared technology led to visible improvements in several skin quality parameters across a wide age range. While the study demonstrated cosmetic benefits, further research is needed to assess the safety profile of these treatments in more detail, as the current methodology was not designed to specifically evaluate device safety.